On the Intune portal, for an application, the mode for assignment can be changed from Included to Excluded. This option is not available in the Recast Patching portal. It can be added to the application in tune Intune Portal after Recast imports the application, but will be removed each time the application is re-imported.
This capability is available in RCT Patching module: https://docs.recastsoftware.com/help/patching-intune-global-deployment-process-settings#program (see Groups Excluded from Deployment part). We are not planning to include this capability to legacy AM product.